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Review Article
Pramya Nanjundan

Comparison of Various Treatment Modalities of Iron Deficiency Anemia in Pregnancy

[Year:2017] [Month:January-March] [Volumn:1 ] [Number:1] [Pages:29] [Pages No:23-26][No of Hits : 2172]


ABSTRACT

More than a quarter of the world’s population is anemic, with about one half of the burden from iron deficiency. Iron deficiency anemia occurs when iron deficiency is severe enough to diminish erythropoiesis and cause the development of anemia. The prevention and treatment of iron deficiency is a major public health goal especially in women, children, and individuals from low-income countries.

Keywords: Chelated iron, Ferrous iron salts, Oral iron supplementation, Parenteral iron.

How to cite this article: Nanjundan P. Comparison of Various Treatment Modalities of Iron Deficiency Anemia in Pregnancy. World J Anemia 2017;1(1):23-26.

Source of support: Nil

Conflict of interest: None


 
Review Article
Vimee Bindra

Anemia in Adolescence

[Year:2017] [Month:January-March] [Volumn:1 ] [Number:1] [Pages:29] [Pages No:18-19][No of Hits : 1796]


ABSTRACT

Adolescent anemia is a global health problem. Prevalence of anemia in girls in India is estimated to be around 56%. Various risk groups are prone to anemia and it leads to long-term consequences. Government has launched national programs to fight adolescent anemia by identifying high-risk groups, supplementing with iron and folic acid tablets and raising awareness about the nutritional anemia.

Keywords: Adolescence, Anemia, Iron deficiency.

How to cite this article: Bindra V. Anemia in Adolescence. World J Anemia 2017;1(1):18-19.

Source of support: Nil

Conflict of interest: None


 
Review Article
Atul Munshi, Sujal Munshi

Iron Deficiency Anemia in Pregnancy: Can We eradicate?

[Year:2017] [Month:April-June] [Volumn:1 ] [Number:2] [Pages:39] [Pages No:36-39][No of Hits : 1664]


ABSTRACT

Iron deficiency anemia (IDA) is the most common type of anemia. Most of the anemic patients, especially women, suffer from mild to severe deficiency of iron. Almost 50% of all pregnant women experience IDA during their pregnancies, and at least 1 out of 5 of girls and women may experience it during their reproductive years. One complete eradication of IDA is not feasible but a try can help us on a long way. Only supplementation is not the answer. Going to the root cause, finding out current situation and managing accordingly by available resources is the correct answer.

Keywords: Anemia, Eradication, Iron deficiency, Pregnancy.

How to cite this article: Munshi A, Munshi S. Iron Deficiency Anemia in Pregnancy: Can We eradicate? World J Anemia 2017;1(2):36-39.

Source of support: Nil

Conflict of interest: None


 
Review Article
Richa Saxena, Tania Banerjee, Rohit B Aniyery

Thalassemia and its Management during Pregnancy

[Year:2017] [Month:January-March] [Volumn:1 ] [Number:1] [Pages:29] [Pages No:5-17][No of Hits : 1191]


ABSTRACT

Thalassemia, also known as Mediterranean anemia, can be considered as the most common monogenetic disease prevailing all across the world. This disorder involves production of abnormal amounts of hemoglobin in the body, which poses a significant burden on the health and economic status of the patients as well as their families. Generally, patients with the thalassemia trait have a normal life expectancy, but individuals with beta thalassemia major mostly die from cardiac complications due to iron overload by the time they reach 30 years of age. Each year, nearly 70,000 babies are born with thalassemia worldwide. Conventional treatment procedures available (e.g., lifelong red blood cell transfusion, iron chelation therapy, and splenectomy) have levied high expenses on the health-care systems.
Thalassemia during pregnancy could be associated with significant complications to the mother as well as her fetus. Therefore, universal antenatal screening for thalassemia carriers should be implemented in populations having a high prevalence of this condition. In order to improve survival among children born with thalassemia, there is a requirement for combined treatment and prevention program during pregnancy. Preconception genetic counseling is strongly advised for all patients with thalassemia. Among the high-risk parents, the most important method for diagnosis of thalassemia is invasive prenatal diagnosis. Following a standard management plan and close monitoring of the maternal and fetal condition during pregnancy helps in considerably reducing the mortality and morbidity associated with this condition.
Novel treatment approaches are recently being developed to correct the resulting α/β globin chain imbalance, in an effort to move beyond the palliative management of this disease and tackle the exact genetic defect involved in its pathogenesis. Three methods for medical treatment of thalassemia have been envisioned: fetal globin gene renaissance by pharmacological compounds being injected into patients, allogeneic hematopoietic stem cell transplantation, and gene therapy. These medical strategies can be considered as the best options prevailing now and are currently under research and clinical studies.

Keywords: α-thalassemia, β-thalassemia, Allogeneic hematopoietic stem cell transplantation, Gene therapy, Iron chelation, Pregnancy management, Splenectomy, Thalassemia

How to cite this article: Saxena R, Banerjee T, Aniyery RB. Thalassemia and its Management during Pregnancy. World J Anemia 2017;1(1):5-17.

Source of support: Nil

Conflict of interest: None


 
Quiz

Quiz on Anemia in Pregnancy

[Year:2017] [Month:April-June] [Volumn:1 ] [Number:2] [Pages:39] [Pages No:68][No of Hits : 1032]


ABSTRACT

Q1.   What is the World Health Organization recommendation in pregnancy for iron and folic acid for developing countries?


 
Quiz

Quiz Questions on Anemia

[Year:2017] [Month:April-June] [Volumn:1 ] [Number:2] [Pages:39] [Pages No:69-70][No of Hits : 924]


ABSTRACT

Anemia, the commonest blood disorder still poorly understood, is prevalent from newborn, to adolescents, in pregnancy, and till menopause! A small quiz may give some answers.


 
Review Article
Neeti Swarup, Shreya Gupta, Chandrani Sagolsem, Zoya Chowdhary, Subhash Gupta, Nidhi Sinha

Atrophic Glossitis: Burning Agony of Nutritional Deficiency Anemia.

[Year:2017] [Month:April-June] [Volumn:1 ] [Number:2] [Pages:39] [Pages No:48-50][No of Hits : 799]


ABSTRACT

Lingual atrophic condition is the loss of ordinary texture and appearance of the dorsal tongue, determined by papillary protrusion, which turns into a soft and smooth aspect. Atrophic glossitis (AG) is a lingual atrophic condition, characterized by loss of fungiform or filiform papilla from the dorsum of tongue. This is generally associated with pain, glossodynia, and burning sensation, glossopyrosis. It is associated with a variety of conditions, local and systemic. Atrophic glossitis is considered to be an important indicator for nutritional deficiency anemias. The study aims at a brief review of AG and its relation to nutritional deficiency anemia.

Keywords: Atrophic glossitis, Epithelial atrophy, Nutritional deficiency anemia.

How to cite this article: Swarup N, Gupta S, Sagolsem C, Chowdhary Z, Gupta S, Sinha N. Atrophic Glossitis: Burning Agony of Nutritional Deficiency Anemia. World J Anemia 2017;1(2):48-50.

Source of support: Nil

Conflict of interest: None


 
Original Article
Rufina Binoy, Neema Acharya

Impact of Anemia on Menstruation and Academic Performance of Adolescent Girls attending Secondary Schools of Rural Wardha District

[Year:2017] [Month:January-March] [Volumn:1 ] [Number:1] [Pages:29] [Pages No:1-4][No of Hits : 620]


ABSTRACT

Introduction: In this research, we hope to understand the effect of anemia on the various menstrual parameters and disorders and on the academic performance of adolescent girls attending secondary schools of rural Wardha.

Materials and methods: Questionnaires were prepared and distributed to the female students who came to attend the adolescent clinic in Acharya Vinoba Bhave Rural Hospital, Sawangi, India, for health checkup. Their hemoglobin was estimated and recorded in their respective questionnaires. Questionnaires were designed to understand in the best way possible the effects of anemia on the menstrual health and academic life of the adolescent girls.

Results: The results revealed a remarkable correlation between the grades of anemia and poor menstrual health; a similar result was seen in case of academic performance as well. It also threw light on the prevalence of anemia, which was recorded as 80% in this study, though most students had only mild grade anemia.

Conclusion: The results of the study revealed that there was a significant relation between anemia and the menstrual parameters and academic performance of the adolescent girls. This study could prove helpful for future researches which aim to provide better quality of life for adolescent girls in terms of general and menstrual health.

Keywords: Academics, Adolescent, Anemia, Menstruation, Rural.

How to cite this article: Binoy R, Acharya N. Impact of Anemia on Menstruation and Academic Performance of Adolescent Girls attending Secondary Schools of Rural Wardha District. World J Anemia 2017;1(1):1-4.

Source of support: Nil

Conflict of interest: None


 
Review Article
Rajalakshmy Prasanth

Prevalence of Anemia in both Developing and Developed Countries around the World

[Year:2017] [Month:April-June] [Volumn:1 ] [Number:2] [Pages:39] [Pages No:40-43][No of Hits : 594]


ABSTRACT

Anemia is a major nutritional problem worldwide and is mainly caused due to iron deficiency. Though it is global in occurrence, it is more of a concern in the developing countries where it is always associated with the socioeconomic status of the people. Anemia is very high (ranging between 80 and >90%) in preschool children, adolescent girls, and pregnant and lactating women. There are about 1.2 billion adolescents in the world, which is equal to one-fifth of the world’s population and their numbers are increasing. This study deals with the prevalence of anemia in the different nations of the world.

Keywords: Complication, Iron deficiency anemia, Prevalence.

How to cite this article: Prasanth R. Prevalence of Anemia in both Developing and Developed Countries around the World. World J Anemia 2017;1(2):40-43.

Source of support: Nil

Conflict of interest: None


 
Review Article
KS Kavitha Gautham

Intravenous Iron Sucrose

[Year:2017] [Month:January-March] [Volumn:1 ] [Number:1] [Pages:29] [Pages No:20-22][No of Hits : 450]


ABSTRACT

Iron deficiency is a major worldwide health problem. There is recent evidence that anemia is the last manifestation of the syndrome. Advances in outlining the physiology of iron deficiency have been made; gaps remain in the current understanding. While oral iron supplement remains the mainstay, some indications for intravenous (IV) administration have developed. In this review, we will highlight the indications and prerequisites of IV iron therapy, dosage, safety, and method of administration.

Keywords: Dose calculation, Intravenous iron preparations, Iron sucrose, Intravenous iron therapy.

How to cite this article: Gautham KSK. Intravenous Iron Sucrose. World J Anemia 2017;1(1):20-22.

Source of support: Nil

Conflict of interest: None


 
Review Article
Shreya Gupta, Subhash Gupta, Neeti Swarup, Harita Sairam, Nidhi Sinha, Suresh S Nair

Orofacial Manifestations associated with Anemia

[Year:2017] [Month:April-June] [Volumn:1 ] [Number:2] [Pages:39] [Pages No:44-47][No of Hits : 441]


ABSTRACT

Oral cavity is the window to the body and is often the area where systemic disease first presents itself. The various tissues including lips, tongue, gingiva, mucosal surfaces, dentition, and bone are involved in the presentation of disease state. The most frequently affected is the periodontium, followed by the oral mucous membrane and the periapical inflammations. The review is not all inclusive; however, it does address some of the most common, as well as a few of the more rare anemia-associated disease states observed in both adults and children.

Keywords: Cheilosis, Congenital hypoplastic anemia, Depapillation, Fanconi anemia, Glossitis, Megaloblastic anemia, Oral lesions, Vitamin B12.

How to cite this article: Gupta S, Gupta S, Swarup N, Sairam H, Sinha N, Nair SS. Orofacial Manifestations associated with Anemia. World J Anemia 2017;1(2):44-47.

Source of support: Nil

Conflict of interest: None


 
Review Article
Richa Saxena, Arun Bhatia, Kanav Midha, Mampi Debnath, Prabhjot Kaur

Malaria: A Cause of Anemia and Its Effect on Pregnancy

[Year:2017] [Month:April-June] [Volumn:1 ] [Number:2] [Pages:39] [Pages No:51-62][No of Hits : 401]


ABSTRACT

Malaria is one of the major health problems in the world. It remains an important cause of very high human morbidity and mortality, especially, among children and pregnant women. It results from the infection of parasites belonging to the genus Plasmodium. Plasmodium falciparum and Plasmodium vivax are the major pathogens responsible for causing human malaria. Approximately 75% of cases are caused by P. falciparum and associated with the mortality rate of approximately 0.5 to 1.0%. Both P. falciparum and P. vivax induce anemia during their erythrocytic stages of infection. Most of the malarial infections are related to some degree of anemia, the severity of which depends upon patient-specific characteristics (e.g., age, innate and acquired resistance, comorbid features, etc.) as well as parasite-specific characteristics (e.g., species, adhesive, and drug-resistant phenotype, etc.). Malarial anemia encompasses reduced production of erythrocytes as well as increased removal of circulating erythrocytes in the bone marrow. Susceptibility to severe malarial anemia is associated with the polymorphisms of the cytokines, which are likely to function by perturbing erythropoiesis. This article reviews the epidemiology, pathophysiology, clinical features, treatment, and various complications occurring due to malarial anemia. The second part of this article also focuses on the effect of malaria during pregnancy. Some significant effects of malaria during pregnancy include spontaneous abortion, preterm delivery, low birthweight, stillbirth, congenital infection, and maternal death.

Keywords: Anemia, Black water anemia, Bone marrow, Cytokine, Dyserythropoiesis, Erythropoiesis, Hemolysis, Malaria, Plasmodium falciparum, Plasmodium vivax.

How to cite this article: Saxena R, Bhatia A, Midha K, Debnath M, Kaur P. Malaria: A Cause of Anemia and Its Effect on Pregnancy. World J Anemia. 2017;1(2):51-62.

Source of support: Nil

Conflict of interest: None


 
Review Article
Amitha Indersen

Fetal Intrauterine Transfusion

[Year:2017] [Month:January-March] [Volumn:1 ] [Number:1] [Pages:29] [Pages No:27-29][No of Hits : 310]


ABSTRACT

Fetal anemia is a recognizable and treatable condition. It requires identification of the etiology to plan a comprehensive treatment strategy. Fetal blood transfusions help tide over crisis and avert fetal cardiovascular decompensation or deterioration due to the anemia. Based on the cause and the fetal condition, the timing and requirement for transfusion are determined. At present, noninvasive monitoring with fetal middle cerebral arterial Doppler peak systolic velocity is the standard for monitoring and diagnosis of fetal anemia.

Keywords: Anemia, Fetal, Intrauterine, Middle cerebral arterial peak systolic velocity, Transfusion.

How to cite this article: Indersen A. Fetal Intrauterine Transfusion. World J Anemia 2017;1(1):27-29.

Source of support: Nil

Conflict of interest: None


 
Case Report
Sourya Acharya, Samarth Shukla, Ajinkya Jamthe, Ankita Tamhane

Sickle Cell Anemia with Megaloblastic Crisis: Deficiency or Demand?

[Year:2017] [Month:April-June] [Volumn:1 ] [Number:2] [Pages:39] [Pages No:63-64][No of Hits : 220]


ABSTRACT

Megaloblastic erythropoiesis has been associated with hemolytic anemias. Sickle cell disease (SCD) presenting as megaloblastosis is a rare phenomenon. We present a case of sickle cell anemia presenting with painful crisis along with megaloblastic blood picture.

Keywords: Anemia, Erythropoiesis, Megaloblastosis, Sickle cell disease.

How to cite this article: Acharya S, Shukla S, Jamthe A, Tamhane A. Sickle Cell Anemia with Megaloblastic Crisis: Deficiency or Demand? World J Anemia 2017;1(2):63-64.

Source of support: Nil

Conflict of interest: None


 
Case Report
Kanika Chopra

A Rare Case of Chronic Abruption-oligohydramnios Sequence at 16 Weeks Pregnancy with Compensated Severe Anemia

[Year:2017] [Month:April-June] [Volumn:1 ] [Number:2] [Pages:39] [Pages No:65-67][No of Hits : 213]


ABSTRACT

Aim: The aim of this article is to report a rare case of chronic abruption-oligohydramnios sequence (CAOS).

Background: Abruptio placentae is usually an acute event needing emergent measures for management, but may present with varied clinical features.

Case report: We describe a rare case of a 20-year-old primigravida at 16 weeks of gestation who presented with complaints of mild pain abdomen off and on for 1 month and minimal bleeding per vaginum for a day. Her vital signs were stable, but there was marked pallor. Obstetric examination revealed uterus corresponding to 20 to 22 weeks of gestation with raised basal tone. Ultrasound findings showed a dead fetus corresponding to 16 weeks of gestation with a large retroplacental collection of 12.5 × 7 cm. The patient was given three units of blood transfusion after which the patient went into spontaneous labor and delivered uneventfully 23 hours after admission.

Conclusion: Recognition of chronic abruption and prompt intervention in our case led to a favorable maternal outcome.

Clinical significance: The diagnosis of chronic abruption should be kept in mind in patients presenting with pain abdomen even in early pregnancy.

Keywords: Chronic abruption, Chronic abruption-oligohydramnios sequence, Oligohydramnios, Second trimester, Severe anemia.

How to cite this article: Chopra K. A Rare Case of Chronic Abruption-oligohydramnios Sequence at 16 Weeks Pregnancy with Compensated Severe Anemia. World J Anemia 2017;1(2):65-67.

Source of support: Nil

Conflict of interest: None


 
Research Article
Shaheen Anjum, Nidhi Garg, Sri Beriwal, Anjum Parvez

High-dose Accelerated vs Low-dose Frequent Regime of Iron Sucrose Therapy in Antenatal and Postnatal Women with Iron Deficiency

[Year:2017] [Month:April-June] [Volumn:1 ] [Number:2] [Pages:39] [Pages No:31-35][No of Hits : 193]


ABSTRACT

Objective: To compare an accelerated high-dose (500 mg) vs low-dose (200 mg) regimen of intravenous iron sucrose in a cohort of iron-deficient anemic antenatal patients in terms of efficacy, safety, and compliance.

Materials and methods: In a prospective hospital-based study, antenatal and postnatal women with anemia attending Jawaharlal Nehru Medical College and Hospital, Aligarh, India, between December 2010 and December 2012 were enrolled. The inclusion criteria were all outpatient and admitted anemic antenatal women ≤ 36 weeks gestation and postnatal women with hemoglobin (Hb) below 10 gm/dL, or serum ferritin ≤ 30 μg/L or transferrin saturation ≤ 40% irrespective of prior oral iron therapy. Patients were excluded from the study if they were hemodynamically unstable, actively bleeding, having fever, or were nauseated or vomiting. Participants were assigned to control and study groups according to simple random sampling. Intravenous iron sucrose group I (500 mg)/group II (200 mg) was infused after test dose on alternate days for the calculated total dose in the study population. Blood and iron indices were measured at baseline and after 2 weeks of administration of last dose. The primary outcome of the study was to assess the rise in Hb and safety of high-dose intravenous iron sucrose.

Results: There was a statistically significant increase in Hb level in patients receiving either regimen, with larger mean increase in group I (2.7 ± 0.4) compared with group II (2.25 ± 6.39). Serum iron and serum ferritin also increased in both fortnightly (p < 0.001). Blood transfusion was avoided by 90.1% in severely anemic cases with Hb < 7. Hospital stay was reduced by 50% in group I.

Conclusion: The accelerated regimen of high-dose (500 mg) intravenous iron sucrose in anemic antenatal patients appears to be safe and effective in correcting anemia, restoring iron stores, and avoiding blood transfusion.

Keywords: Anemia, Iron deficiency, Iron sucrose.

How to cite this article: Anjum S, Garg N, Beriwal S, Parvez A. High-dose Accelerated vs Low-dose Frequent Regime of Iron Sucrose Therapy in Antenatal and Postnatal Women with Iron Deficiency. World J Anemia 2017;1(2):31-35.

Source of support: Nil

Conflict of interest: None


 
Editorial
Sourya Acharya, Narendra Malhotra

Anemia: Old Disease, New Solutions!

[Year:2017] [Month:April-June] [Volumn:1 ] [Number:2] [Pages:39] [Pages No:vi-vii][No of Hits : 174]


ABSTRACT

Anemia how old? Lo! It was one gift from the Pandora’s box. As true as the devil, it is there since the genesis of life as a symbiotic friend of nature. As a part of female physiology it opened its saga from iron deficiency and evolved with us since time immemorial with its many forms and features.


 
Editorial 1
MB Agarwal

Editorial 1

[Year:2017] [Month:January-March] [Volumn:1 ] [Number:1] [Pages:29] [Pages No:vi-vii][No of Hits : 125]


ABSTRACT

Anemia is a condition in which there is a deficiency of red cells or hemoglobin in the blood, resulting in pallor and weakness. According to the World Health Organization report, anemia affects 1.62 billion people, which corresponds to 24.8% of the world population. The highest prevalence is in preschool-age children and the lowest prevalence is amongst men. However, the population group with the greatest number of individuals affected is non-pregnant women.


 
Editorial 2
Narendra Malhotra, Seema Pandey, Jaideep Malhotra

Why Anemia Journal?

[Year:2017] [Month:January-March] [Volumn:1 ] [Number:1] [Pages:29] [Pages No:viii-ix][No of Hits : 109]


ABSTRACT

Investment in nutrition is crucial to future efforts to improve the health of women, children, and adolescents; the potential human, societal, and economic gains from such investment are substantial.



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